|Application ||WB, IHC, E|
|Other Accession||NP_005832.1, NP_955359.1, 10252|
|Calculated MW||35122 Da|
|Other Names||Protein sprouty homolog 1, Spry-1, SPRY1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Sprouty Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor)|
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Provided below are standard protocols that you may find useful for product applications.
NP_005832.1 and NP_955359.1 represent varients of the same protein.
Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. Hanafusa H, Torii S, Yasunaga T, Matsumoto K, Nishida E. J Biol Chem. 2004 May 28;279(22):22992-5. PMID: 15031289
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