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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > RIF1 (aa 2076-2089) Antibody (internal region)
RIF1 (aa 2076-2089) Antibody (internal region)
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q5UIP0 |
| Other Accession | NP_060621.3, 55183 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 274466 Da |
| Gene ID | 55183 |
|---|---|
| Other Names | Telomere-associated protein RIF1, Rap1-interacting factor 1 homolog, RIF1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RIF1 (aa 2076-2089) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RIF1 {ECO:0000303|PubMed:15342490, ECO:0000312|HGNC:HGNC:23207} |
|---|---|
| Function | Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes NHEJ of dysfunctional telomeres (By similarity). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q6PR54}. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (By similarity). Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs) (PubMed:15342490). Does not associate with normal telomere structures (PubMed:15342490, PubMed:15583028). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (PubMed:15583028) {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:15583028} |
| Tissue Location | Highly expressed in testis. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise an epitope corresponding to aa 2076-2089 of human RIF1 protein.
References
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T. Genes Dev. 2004 Sep 1;18(17):2108-19. PMID: 15342490
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$ 341.00
Cat# AF2421a
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