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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > PICT1 / GLTSCR2 Antibody (internal region)
PICT1 / GLTSCR2 Antibody (internal region)
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9NZM5 |
| Other Accession | NP_056525.2, 29997, 68077 (mouse), 292624 (rat) |
| Predicted | Human, Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 54389 Da |
| Gene ID | 29997 |
|---|---|
| Other Names | Glioma tumor suppressor candidate region gene 2 protein, p60, GLTSCR2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PICT1 / GLTSCR2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOP53 (HGNC:4333) |
|---|---|
| Function | Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081). |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Note=In the nucleolus may be more specifically localized to the fibrillar center (PubMed:27729611). Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53 (PubMed:22522597, PubMed:24923447, PubMed:27323397, PubMed:26903295) Also detected in the cytosol (PubMed:24923447, PubMed:27824081) |
| Tissue Location | Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise a sequence corresponding to aa 38-51 of human PICT1 protein.
References
Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. Okahara F, Ikawa H, Kanaho Y, Maehama T. J Biol Chem. 2004 Oct 29;279(44):45300-3. Epub 2004 Sep 07. PMID: 15355975
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$ 216.00
Cat# AF2423a
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