RASA3 / GAP1IP4BP Antibody (internal region, near the C-Term)
Peptide-affinity purified goat antibody
|Other Accession||NP_031394.2, 22821|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||95699 Da|
|Other Names||Ras GTPase-activating protein 3, GAP1(IP4BP), Ins P4-binding protein, RASA3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASA3 / GAP1IP4BP Antibody (internal region, near the C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.|
|Cellular Location||Cell membrane.|
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NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. Kuai J, Wooters J, Hall JP, Rao VR, Nickbarg E, Li B, Chatterjee-Kishore M, Qiu Y, Lin LL. J Biol Chem. 2004 Dec 17;279(51):53266-71. Epub 2004 Oct 13. PMID: 15485837
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