|Application ||IHC, E|
|Other Accession||NP_001038.1, 6715|
|Calculated MW||29459 Da|
|Other Names||3-oxo-5-alpha-steroid 4-dehydrogenase 1, 126.96.36.199, SR type 1, Steroid 5-alpha-reductase 1, S5AR 1, SRD5A1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SRD5A1 / 5-alpha reductase 1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.|
|Cellular Location||Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Liver and prostate (at a low level).|
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Provided below are standard protocols that you may find useful for product applications.
The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. Iczkowski KA, Qiu J, Qian J, Somerville MC, Rittmaster RS, Andriole GL, Bostwick DG. Urology. 2005 Jan;65(1):76-82. PMID: 15667867
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