|Application ||WB, IHC, E|
|Other Accession||NP_055918.2, 23129|
|Predicted||Pig, Dog, Cow|
|Calculated MW||212007 Da|
|Other Names||Plexin-D1, PLXND1, KIAA0620|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Plexin D1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.|
|Cellular Location||Cell membrane; Single-pass membrane protein|
|Tissue Location||Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Science. 2005 Jan 14;307(5707):265-8. Epub 2004 Nov 18. PMID: 15550623
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