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AGRP / Agouti-related protein Antibody (C-Term)

Peptide-affinity purified goat antibody

     
  • IHC - AGRP / Agouti-related protein Antibody (C-Term) AF2437a
    AF2437a (0.05 µg/ml) staining of PFA-perfused cryosection of Human Hypothalamus. Antigen retrieval with citrate buffer pH 6 at 80C for 30min, HRP-staining with Ni-DAB after Biotin-SP-antigoat amplification. Data obtained by Prof. Erik Hrabovszky, Inst, Exp, Med., Budapest, Hungary.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession O00253
Other Accession NP_001129.1, NP_015531.1, 181
Reactivity Human
Predicted Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 14440 Da
Additional Information
Gene ID 181
Other Names Agouti-related protein, AGRP, AGRT, ART
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAGRP / Agouti-related protein Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGRP
Synonyms AGRT, ART
Function Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Cellular Location Secreted. Golgi apparatus lumen
Tissue Location Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney
Research Areas
Citations (0)
citation

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Background

This antibody is expected to recognise both reported isoforms (as represented by NP_001129; NP_015531)

References

Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Breen TL, Conwell IM, Wardlaw SL. Brain Res. 2005 Jan 25;1032(1-2):141-8. PMID: 15680952

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$ 341.00
Cat# AF2437a
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