|Application ||IHC, E|
|Other Accession||NP_001129.1, NP_015531.1, 181|
|Calculated MW||14440 Da|
|Other Names||Agouti-related protein, AGRP, AGRT, ART|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AGRP / Agouti-related protein Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.|
|Cellular Location||Secreted. Golgi apparatus lumen|
|Tissue Location||Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (as represented by NP_001129; NP_015531)
Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Breen TL, Conwell IM, Wardlaw SL. Brain Res. 2005 Jan 25;1032(1-2):141-8. PMID: 15680952
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