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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > VPS11 Antibody (internal region)
VPS11 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q9H270 |
| Other Accession | NP_068375.3, 55823, 71732 (mouse) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 107837 Da |
| Gene ID | 55823 |
|---|---|
| Other Names | Vacuolar protein sorting-associated protein 11 homolog, hVPS11, RING finger protein 108, VPS11, RNF108 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VPS11 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VPS11 |
|---|---|
| Synonyms | RNF108 |
| Function | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). |
| Cellular Location | Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome {ECO:0000269|PubMed:21148287, ECO:0000305}. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle |
| Tissue Location | Ubiquitous. Expression was highest in heart and low in lung |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. Kim BY, Kramer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C. J Biol Chem. 2001 Aug 3;276(31):29393-402. Epub 2001 May 29. PMID: 11382755
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$ 341.00
Cat# AF2444a
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