|Application ||IHC, E|
|Other Accession||NP_115934.1, 55997|
|Calculated MW||24612 Da|
|Other Names||Cryptic protein, Cryptic family protein 1, CFC1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CFC1 / Cripto-1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI- signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates|
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Role of human cripto-1 in tumor angiogenesis. Bianco C, Strizzi L, Ebert A, Chang C, Rehman A, Normanno N, Guedez L, Salloum R, Ginsburg E, Sun Y, Khan N, Hirota M, Wallace-Jones B, Wechselberger C, Vonderhaar BK, Tosato G, Stetler-Stevenson WG, Sanicola M, Salomon DS. J Natl Cancer Inst. 2005 Jan 19;97(2):132-41. PMID: 15657343
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