|Other Accession||NP_001005738.1, NP_001453.1, 2358|
|Calculated MW||38964 Da|
|Other Names||N-formyl peptide receptor 2, FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP, FPR2, FPRH1, FPRL1, LXA4R|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FPRL1 (aa328-339) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FPRH1, FPRL1, LXA4R|
|Function||Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis|
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Provided below are standard protocols that you may find useful for product applications.
Both reported variants (NP_001005738.1 and NP_001453.1) are identical proteins.
Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. Vachier I, Bonnans C, Chavis C, Farce M, Godard P, Bousquet J, Chanez P. J Allergy Clin Immunol. 2005 Jan;115(1):55-60. PMID: 15637547
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