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FPRL1 (aa328-339) Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P25090 |
| Other Accession | NP_001005738.1, NP_001453.1, 2358 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 38964 Da |
| Gene ID | 2358 |
|---|---|
| Other Names | N-formyl peptide receptor 2, FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP, FPR2, FPRH1, FPRL1, LXA4R |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FPRL1 (aa328-339) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FPR2 |
|---|---|
| Synonyms | FPRH1, FPRL1, LXA4R |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti- inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL- induced osteoclast differentiation (By similarity). Acts as a receptor for humanin (PubMed:15465011). |
| Cellular Location | Cell membrane; Multi-pass membrane protein Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011). |
| Tissue Location | Detected in lung, bone marrow, neutrophils, spleen and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Both reported variants (NP_001005738.1 and NP_001453.1) are identical proteins.
References
Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound. Vachier I, Bonnans C, Chavis C, Farce M, Godard P, Bousquet J, Chanez P. J Allergy Clin Immunol. 2005 Jan;115(1):55-60. PMID: 15637547
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