|Other Accession||NP_003948.2, 9024, 75770 (mouse), 293631 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||81633 Da|
|Other Names||Serine/threonine-protein kinase BRSK2, 18.104.22.168, Brain-selective kinase 2, 22.214.171.124, Brain-specific serine/threonine-protein kinase 2, BR serine/threonine-protein kinase 2, Serine/threonine-protein kinase 29, Serine/threonine-protein kinase SAD-A, BRSK2, C11orf7, PEN11B, SADA, STK29|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BRSK2 / STK29 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C11orf7, PEN11B, SADA, STK29|
|Function||Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin|
|Tissue Location||Detected in pancreas islets (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian SAD kinases are required for neuronal polarization. Kishi M, Pan YA, Crump JG, Sanes JR. Science. 2005 Feb 11;307(5711):929-32. PMID: 15705853
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