|Other Accession||NP_004091.3, NP_742102.2, NP_742103.1, 2070, 14051 (mouse)|
|Calculated MW||69505 Da|
|Other Names||Eyes absent homolog 4, 188.8.131.52, EYA4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EYA4 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Highly expressed in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoforms a, c and d (NP_004091.3, NP_742102.1 and NP_742103.1 respectively).
Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Schonberger J, Wang L, Shin JT, Kim SD, Depreux FF, Zhu H, Zon L, Pizard A, Kim JB, Macrae CA, Mungall AJ, Seidman JG, Seidman CE. Nat Genet. 2005 Feb 27; [Epub ahead of print] PMID: 15735644
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