|Other Accession||NP_001990.2, 2201|
|Predicted||Human, Dog, Cow|
|Calculated MW||314775 Da|
|Other Names||Fibrillin-2, FBN2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Fibrillin 2 Antibody (internal region, near the C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Fibrillin-2: Fibrillins are structural components of 10- 12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera. Not expressed in the neural retina|
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Provided below are standard protocols that you may find useful for product applications.
Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development. Quondamatteo F, Reinhardt DP, Charbonneau NL, Pophal G, Sakai LY, Herken R. Matrix Biol. 2002 Dec;21(8):637-46. PMID: 12524050
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