|Other Accession||NP_055696.3, 9937|
|Calculated MW||116400 Da|
|Other Names||DNA cross-link repair 1A protein, SNM1 homolog A, hSNM1, hSNM1A, DCLRE1A, KIAA0086, SNM1, SNM1A|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNM1 / DCLRE1A (internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0086, SNM1, SNM1A|
|Function||May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.|
|Cellular Location||Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross- linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1|
|Tissue Location||Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ. Mol Cell Biol. 2004 Dec;24(23):10448-55. PMID: 15542852
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