KIAA0319 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q5VV43 |
Other Accession | NP_055624.2, 9856 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 117763 Da |
Gene ID | 9856 |
---|---|
Other Names | Dyslexia-associated protein KIAA0319, KIAA0319 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KIAA0319 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KIAA0319 |
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Function | Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. |
Cellular Location | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted |
Tissue Location | Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum. |
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Provided below are standard protocols that you may find useful for product applications.
References
Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. Cope N, Harold D, Hill G, Moskvina V, Stevenson J, Holmans P, Owen MJ, O'Donovan MC, Williams J. Am J Hum Genet. 2005 Apr;76(4):581-91. Epub 2005 Feb 16. PMID: 15717286
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