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TRIM5 / RNF88 (alpha isoform) Antibody (internal region)

Peptide-affinity purified goat antibody

  • IHC - TRIM5 / RNF88 (alpha isoform) Antibody (internal region) AF2491a
    AF2491a (4 µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C035
Other Accession NP_149023.1, 85363
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 56338 Da
Additional Information
Gene ID 85363
Other Names Tripartite motif-containing protein 5, 6.3.2.-, RING finger protein 88, TRIM5, RNF88
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM5 / RNF88 (alpha isoform) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM5
Synonyms RNF88
Function Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF- kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equine infectious anemia virus (EIAV).
Cellular Location Cytoplasm, P-body Note=Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies.
Research Areas
Citations (0)

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This antibody is expected to recognise isoform alpha (NP_149023.1) only.


Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Berthoux L, Sebastian S, Sokolskaja E, Luban J. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14849-53. Epub 2005 Oct 3. PMID: 16203999

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$ 325.00
Cat# AF2491a
(40 western blots)
Availability: 7-10 days
Bulk Size
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