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NEUROD2 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q15784 |
| Other Accession | NP_006151.3, 4761 |
| Predicted | Human, Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 41361 Da |
| Gene ID | 4761 |
|---|---|
| Other Names | Neurogenic differentiation factor 2, NeuroD2, Class A basic helix-loop-helix protein 1, bHLHa1, NeuroD-related factor, NDRF, NEUROD2, BHLHA1, NDRF |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NEUROD2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NEUROD2 |
|---|---|
| Synonyms | BHLHA1, NDRF |
| Function | Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Lin CH, Hansen S, Wang Z, Storm DR, Tapscott SJ, Olson JM. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14877-82. Epub 2005 Oct 3. PMID: 16203979
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