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Stearoyl-CoA desaturase Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, FC, E |
|---|---|
| Primary Accession | O00767 |
| Other Accession | NP_005054.3, 6319 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 41523 Da |
| Gene ID | 6319 |
|---|---|
| Other Names | Acyl-CoA desaturase, 1.14.19.1, Delta(9)-desaturase, Delta-9 desaturase, Fatty acid desaturase, Stearoyl-CoA desaturase, SCD |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Stearoyl-CoA desaturase Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCD |
|---|---|
| Function | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:18765284, ECO:0000305} |
| Tissue Location | Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Zhang S, Yang Y, Shi Y. Biochem J. 2004 Dec 20; [Epub ahead of print] PMID: 15610069
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