|Application ||IHC, E|
|Other Accession||NP_000946.2, 5731|
|Calculated MW||41801 Da|
|Other Names||Prostaglandin E2 receptor EP1 subtype, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostanoid EP1 receptor, PTGER1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EP1 receptor / PTGER1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart|
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Provided below are standard protocols that you may find useful for product applications.
Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. Han C, Wu T. J Biol Chem. 2005 Jun 24;280(25):24053-63. Epub 2005 Apr 26. PMID: 15855163
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