|Other Accession||NP_001495.1, 2833, 12766 (mouse), 84475 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||40660 Da|
|Other Names||C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor, CD183, CXCR3, GPR9|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CXCR3 / GPR9 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 3: Mediates the activity of CXCL11.|
|Cellular Location||Isoform 1: Cell membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level)|
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CXCR3/CXCL10 expression in the synovium of children with juvenile idiopathic arthritis. Martini G, Zulian F, Calabrese F, Bortoli M, Facco M, Cabrelle A, Valente M, Zacchello F, Agostini C. Arthritis Res Ther. 2005;7(2):R241-9. Epub 2005 Jan 7. PMID: 15743470
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