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Snail homolog 1 / SNAI1 Antibody (N-Term)

Peptide-affinity purified goat antibody

  • WB - Snail homolog 1 / SNAI1 Antibody (N-Term) AF2531a
    AF2531a (0.1 µg/ml) staining of A431 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95863
Other Accession NP_005976.2, 6615, 20613 (mouse), 116490 (rat)
Reactivity Human, Mouse
Predicted Rat
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 29083 Da
Additional Information
Gene ID 6615
Other Names Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna, SNAI1, SNAH
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSnail homolog 1 / SNAI1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNAI1
Synonyms SNAH
Function Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Cellular Location Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs
Tissue Location Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
Research Areas
Citations (0)

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Snail blocks the cell cycle and confers resistance to cell death. Vega S, Morales AV, Ocana OH, Valdes F, Fabregat I, Nieto MA. Genes Dev. 2004 May 15;18(10):1131-43. PMID: 15155580

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$ 325.00
Cat# AF2531a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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