|Other Accession||NP_663731.1, 23175, 14245 (mouse)|
|Predicted||Human, Mouse, Dog|
|Calculated MW||98664 Da|
|Other Names||Phosphatidate phosphatase LPIN1, 22.214.171.124, Lipin-1, LPIN1, KIAA0188|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Lipin 1 (Internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).|
|Cellular Location||Nucleus membrane. Cytoplasm, cytosol. Endoplasmic reticulum membrane|
|Tissue Location||Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Suviolahti E, Reue K, Cantor RM, Phan J, Gentile M, Naukkarinen J, Soro-Paavonen A, Oksanen L, Kaprio J, Rissanen A, Salomaa V, Kontula K, Taskinen MR, Pajukanta P, Peltonen L. Hum Mol Genet. 2006 Feb 1;15(3):377-86. Epub 2005 Dec 15. PMID: 16357106
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