|Application ||IHC, E|
|Other Accession||NP_036563.1, NP_001171600.1, 9723, 20349 (mouse)|
|Predicted||Mouse, Rat, Pig, Dog|
|Calculated MW||89228 Da|
|Other Names||Semaphorin-3E, SEMA3E, KIAA0331, SEMAH|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Semaphorin 3E (internal) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_036563.1; NP_001171600.1).
Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Science. 2005 Jan 14;307(5707):265-8. Epub 2004 Nov 18. PMID: 15550623
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