|Other Accession||NP_055099.1, NP_001014841.1, 23154, 26562 (mouse), 89791 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||78864 Da|
|Other Names||Neurochondrin, NCDN, KIAA0607|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Neurochondrin Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.|
|Cellular Location||Cytoplasm, cytosol. Cell projection, dendrite. Note=Localizes to somatic regions of neurons|
|Tissue Location||Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord Weakly expressed in ovary, testis, fetal brain and small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize both reported isoforms (NP_055099.1; NP_001014841.1). Reported variants represent identical protein (NP_055099.1; NP_001014839.1).
Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure. Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, Fukamizu A. J Biol Chem. 2005 May 27;280(21):20503-8. Epub 2005 Mar 24. PMID: 15790563
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