|Other Accession||NP_079133.3, 79915|
|Calculated MW||207570 Da|
|Other Names||ATPase family AAA domain-containing protein 5, Chromosome fragility-associated gene 1 protein, ATAD5, C17orf41, FRAG1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATAD5 / FRAG1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis.|
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Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Ishii H, Inageta T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9655-60. Epub 2005 Jun 27. PMID: 15983387
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