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Carabin / TBC1D10C Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q8IV04 |
| Other Accession | NP_940919.1, 374403, 108995 (mouse) |
| Predicted | Human, Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 49712 Da |
| Gene ID | 374403 |
|---|---|
| Other Names | Carabin, TBC1 domain family member 10C, TBC1D10C |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Carabin / TBC1D10C Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TBC1D10C |
|---|---|
| Function | Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. |
| Tissue Location | Most abundant in spleen and peripheral blood leukocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO. Nature. 2007 Jan 25;445(7126):433-6. Epub 2007 Jan 17. PMID: 17230191
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