|Other Accession||NP_940919.1, 374403, 108995 (mouse)|
|Predicted||Human, Mouse, Rat, Pig, Dog|
|Calculated MW||49712 Da|
|Other Names||Carabin, TBC1 domain family member 10C, TBC1D10C|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Carabin / TBC1D10C Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.|
|Tissue Location||Most abundant in spleen and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO. Nature. 2007 Jan 25;445(7126):433-6. Epub 2007 Jan 17. PMID: 17230191
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