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NAT10 / hALP Antibody (internal region, near the C-Term)
Peptide-affinity purified goat antibody
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Application 
| IHC, E |
|---|---|
| Primary Accession | Q9H0A0 |
| Other Accession | NP_078938.1, 55226, 98956 (mouse) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 115730 Da |
| Gene ID | 55226 |
|---|---|
| Other Names | N-acetyltransferase 10, 2.3.1.-, NAT10, ALP, KIAA1709 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NAT10 / hALP Antibody (internal region, near the C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAT10 {ECO:0000255|HAMAP-Rule:MF_03211} |
|---|---|
| Synonyms | ALP, KIAA1709 |
| Function | RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003). |
| Cellular Location | Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03211, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25653167}. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. |
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Effective gene suppression using small interfering RNA in hard-to-transfect human T cells. Yin J, Ma Z, Selliah N, Shivers DK, Cron RQ, Finkel TH. J Immunol Methods. 2006 May 30;312(1-2):1-11. Epub 2006 Mar 24. PMID: 16603179
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$ 335.00
Cat# AF2566a
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