|Application ||IHC, E|
|Other Accession||NP_078938.1, 55226, 98956 (mouse)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||115730 Da|
|Other Names||N-acetyltransferase 10, 2.3.1.-, NAT10, ALP, KIAA1709|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NAT10 / hALP Antibody (internal region, near the C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division.|
|Cellular Location||Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase|
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Effective gene suppression using small interfering RNA in hard-to-transfect human T cells. Yin J, Ma Z, Selliah N, Shivers DK, Cron RQ, Finkel TH. J Immunol Methods. 2006 May 30;312(1-2):1-11. Epub 2006 Mar 24. PMID: 16603179
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