|Other Accession||NP_067021.1, NP_872580.1, 58190, 227292 (mouse), 363249 (rat)|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||29203 Da|
|Other Names||Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, 126.96.36.199, Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1, CTDSP1, NIF3, NLIIF, SCP1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTDSP1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NIF3, NLIIF, SCP1|
|Function||Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.|
|Cellular Location||Nucleus. Note=Colocalizes with RNA polymerase II|
|Tissue Location||Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both reported isoforms (NP_067021.1and NP_872580.1).
Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Mol Cell. 2006 Dec 8;24(5):759-70. PMID: 17157258 [PubMed - indexed for MEDLINE
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