|Other Accession||NP_996800.1, NP_996798.1, NP_055195.1, 27018|
|Predicted||Human, Mouse, Rat|
|Calculated MW||12959 Da|
|Other Names||Protein BEX3, Brain-expressed X-linked protein 3, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, p75NTR-associated cell death executor, NGFRAP1, BEX3, DXS6984E, NADE|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NGFRAP1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BEX3, DXS6984E, NADE|
|Function||May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity).|
|Tissue Location||Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise isoform a (NP_996800.1) and isoform b (NP_996798.1 and NP_055195.1).
Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Passino MA, Adams RA, Sikorski SL, Akassoglou K. Science. 2007 Mar 30;315(5820):1853-6. PMID: 17395831
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