|Other Accession||NP_001073899.1, 27324, 244579 (mouse), 291908 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||63342 Da|
|Other Names||TOX high mobility group box family member 3, CAG trinucleotide repeat-containing gene F9 protein, Trinucleotide repeat-containing gene 9 protein, TOX3, CAGF9, TNRC9|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TOX3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region.|
|Tissue Location||Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe|
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Genome-wide association study identifies novel breast cancer susceptibility loci. Easton DF et al. Nature. 2007 Jun 28;447(7148):1087-93. PMID: 17529967
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