|Application ||WB, E|
|Other Accession||NP_061947.1, 54567|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||74605 Da|
|Other Names||Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DLL4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in vascular endothelium.|
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Provided below are standard protocols that you may find useful for product applications.
Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Ohlstein B, Spradling A. Science. 2007 Feb 16;315(5814):988-92. PMID: 17303754
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