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DLL4 Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • WB - DLL4 Antibody (internal region) AF2621a
    AF2621a (0.3 µg/ml) staining of Human (A), Mouse(B) and Rat (C) Lung lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NR61
Other Accession NP_061947.1, 54567
Reactivity Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 74605 Da
Additional Information
Gene ID 54567
Other Names Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDLL4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLL4
Function Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in vascular endothelium.
Research Areas
Citations (0)

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Background

Notch signaling

References

Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Ohlstein B, Spradling A. Science. 2007 Feb 16;315(5814):988-92. PMID: 17303754

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$ 335.00
Cat# AF2621a
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