|Other Accession||NP_037481.1, 29937, 66208 (mouse), 289380 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||18856 Da|
|Other Names||Neudesin, Cell immortalization-related protein 2, Neuron-derived neurotrophic factor, Secreted protein of unknown function, SPUF protein, NENF, CIR2, SPUF|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Neudesin / NENF Antibody (internal region, near the C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.|
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Provided below are standard protocols that you may find useful for product applications.
Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells. Kimura I, Konishi M, Miyake A, Fujimoto M, Itoh N. J Neurosci Res. 2006 Jun;83(8):1415-24. PMID: 16547973
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