|Application ||IHC, E|
|Other Accession||NP_071343.2, 63874, 105501 (mouse)|
|Predicted||Human, Mouse, Dog|
|Calculated MW||38794 Da|
|Other Names||Abhydrolase domain-containing protein 4, 3.1.1.-, Alpha/beta-hydrolase 4, Lyso-N-acylphosphatidylethanolamine lipase, ABHD4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABHD4 (aa 177 to 187) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. Simon GM, Cravatt BF. J Biol Chem. 2006 Sep 8;281(36):26465-72. Epub 2006 Jul 3. PMID: 16818490
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