|Application ||IHC, E|
|Other Accession||NP_004853.2, NP_001129945.1, 9516, 56722 (mouse), 65161 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||17107 Da|
|Other Names||Lipopolysaccharide-induced tumor necrosis factor-alpha factor, LPS-induced TNF-alpha factor, Small integral membrane protein of lysosome/late endosome, p53-induced gene 7 protein, LITAF, PIG7, SIMPLE|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LITAF Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression.|
|Cellular Location||Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with membranes of lysosomes|
|Tissue Location||Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is excpected to crossreact with both reported isoforms (NP_004853.2; NP_001129945.1).
LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Tang X, Metzger D, Leeman S, Amar S. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13777-82. Epub 2006 Sep 5. Erratum PMID: 16954198
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