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PTBP2 Antibody (internal region)

Peptide-affinity purified goat antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession Q9UKA9
Other Accession NP_067013.1, 58155, 56195 (mouse), 310820 (rat)
Predicted Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Additional Information
Other Names Polypyrimidine tract-binding protein 2, Neural polypyrimidine tract-binding protein, Neurally-enriched homolog of PTB, PTB-like protein, PTBP2, NPTB, PTB, PTBLP
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTBP2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTBP2
Synonyms NPTB, PTB, PTBLP
Function RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.
Cellular Location Nucleus.
Tissue Location Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues Isoform 3 and isoform 4 are expressed in non-neuronal tissues Isoform 5 and isoform 6 are truncated forms expressed in non- neuronal tissues. EMBL; AF176085; AAF14284.1; -; mRNA EMBL; AB051232; BAB71742.1; -; mRNA EMBL; AB051233; BAB71743.1; -; mRNA EMBL; AF530580; AAM94624.1; -; mRNA EMBL; AF530581; AAM94625.1; -; mRNA EMBL; AF530582; AAM94626.1; -; mRNA EMBL; AF530583; AAM94627.1; -; mRNA EMBL; BK000526; DAA00060.1; -; mRNA EMBL; AL357150; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC016582; AAH16582.1; -; mRNA CCDS; CCDS72828.1; -. [Q9UKA9-3] CCDS; CCDS72829.1; -. [Q9UKA9-4] CCDS; CCDS72830.1; -. [Q9UKA9-2] CCDS; CCDS754.1; -. [Q9UKA9-1] RefSeq; NP_001287914.1; NM_001300985.1. [Q9UKA9-3] RefSeq; NP_001287915.1; NM_001300986.1 RefSeq; NP_001287916.1; NM_001300987.1 RefSeq; NP_001287917.1; NM_001300988.1. [Q9UKA9-4] RefSeq; NP_001287918.1; NM_001300989.1. [Q9UKA9-2] RefSeq; NP_001287919.1; NM_001300990.1 RefSeq; NP_067013.1; NM_021190.3. [Q9UKA9-1] UniGene; Hs.596061; - UniGene; Hs.743449; - PDB; 2CQ1; NMR; -; A=51-138 PDB; 2MJU; NMR; -; A=325-531 PDB; 4CQ1; X-ray; 1.69 A; A/B/C/D/E/F/G/H=336-531 PDBsum; 2CQ1; - PDBsum; 2MJU; - PDBsum; 4CQ1; - ProteinModelPortal; Q9UKA9; - SMR; Q9UKA9; - BioGrid; 121796; 23 CORUM; Q9UKA9; - IntAct; Q9UKA9; 23 MINT; Q9UKA9; - STRING; 9606.ENSP00000412788; - iPTMnet; Q9UKA9; - PhosphoSitePlus; Q9UKA9; - SwissPalm; Q9UKA9; - BioMuta; PTBP2; - DMDM; 74761983; - REPRODUCTION-2DPAGE; IPI00647067; - EPD; Q9UKA9; - PaxDb; Q9UKA9; - PeptideAtlas; Q9UKA9; - PRIDE; Q9UKA9; - ProteomicsDB; 84754; - ProteomicsDB; 84755; -. [Q9UKA9-2] ProteomicsDB; 84756; -. [Q9UKA9-3] ProteomicsDB; 84757; -. [Q9UKA9-4] ProteomicsDB; 84758; -. [Q9UKA9-5] ProteomicsDB; 84759; -. [Q9UKA9-6] DNASU; 58155; - Ensembl; ENST00000370197; ENSP00000359216; ENSG00000117569. [Q9UKA9-3] Ensembl; ENST00000370198; ENSP00000359217; ENSG00000117569. [Q9UKA9-4] Ensembl; ENST00000426398; ENSP00000412788; ENSG00000117569. [Q9UKA9-1] Ensembl; ENST00000609116; ENSP00000477024; ENSG00000117569. [Q9UKA9-2] GeneID; 58155; - KEGG; hsa:58155; - UCSC; uc001drn.3; human. [Q9UKA9-1] CTD; 58155; - DisGeNET; 58155; - EuPathDB; HostDB:ENSG00000117569.18; - GeneCards; PTBP2; - HGNC; HGNC:17662; PTBP2 HPA; HPA047420; - MIM; 608449; gene neXtProt; NX_Q9UKA9; - OpenTargets; ENSG00000117569; - PharmGKB; PA33935; - eggNOG; KOG1190; Eukaryota eggNOG; ENOG410XPMZ; LUCA GeneTree; ENSGT00550000074508; - HOVERGEN; HBG069548; - InParanoid; Q9UKA9; - KO; K14948; - OMA; AQQAKLX; - OrthoDB; EOG091G0Z5R; - PhylomeDB; Q9UKA9; - TreeFam; TF319824; - ChiTaRS; PTBP2; human EvolutionaryTrace; Q9UKA9; - GeneWiki; PTBP2; - GenomeRNAi; 58155; - PRO; PR:Q9UKA9; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000117569; - CleanEx; HS_PTBP2; - Genevisible; Q9UKA9; HS GO; GO:0030426; C:growth cone; IEA:Ensembl GO; GO:0043025; C:neuronal cell body; IEA:Ensembl GO; GO:0005681; C:spliceosomal complex; IEA:Ensembl GO; GO:0003729; F:mRNA binding; IEA:Ensembl GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0021549; P:cerebellum development; IEA:Ensembl GO; GO:0006376; P:mRNA splice site selection; IEA:Ensembl GO; GO:0033119; P:negative regulation of RNA splicing; IDA:UniProtKB GO; GO:2000177; P:regulation of neural precursor cell proliferation; IEA:Ensembl GO; GO:0021510; P:spinal cord development; IEA:Ensembl CDD; cd12778; RRM1_PTBP2; 1 CDD; cd12693; RRM2_PTBP1_like; 1 CDD; cd12696; RRM3_PTBP2; 1 CDD; cd12702; RRM4_PTBP2; 1 Gene3D; 3.30.70.330; -; 4 InterPro; IPR006536; HnRNP-L/PTB InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf InterPro; IPR034798; PTBP1/2/3_RRM2 InterPro; IPR035002; PTBP2_RRM1 InterPro; IPR034799; PTBP2_RRM3 InterPro; IPR034800; PTBP2_RRM4 InterPro; IPR035979; RBD_domain_sf InterPro; IPR000504; RRM_dom Pfam; PF00076; RRM_1; 2 SMART; SM00360; RRM; 4 SUPFAM; SSF54928; SSF54928; 4 TIGRFAMs; TIGR01649; hnRNP-L_PTB; 1 PROSITE; PS50102; RRM; 4 1: Evidence at protein level; 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding CHAIN 1 531 Polypyrimidine tract-binding protein 2 /FTId=PRO_0000232928 DOMAIN 59 133 RRM 1. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 181 257 RRM 2. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 338 412 RRM 3. {ECO:0000255|PROSITE- ProRule:PRU00176} DOMAIN 455 529 RRM 4. {ECO:0000255|PROSITE- ProRule:PRU00176} COMPBIAS 315 324 Poly-Ala MOD_RES 1 1 N-acetylmethionine MOD_RES 26 26 Phosphoserine {ECO:0000250|UniProtKB:Q91Z31} MOD_RES 27 27 Phosphoserine {ECO:0000250|UniProtKB:Q91Z31} MOD_RES 308 308 Phosphoserine VAR_SEQ 302 302 A -> GLPVAA (in isoform 3, isoform 4 and isoform 6) /FTId=VSP_018015 VAR_SEQ 349 356 MVTPQSLF -> VFMEMCSV (in isoform 5 and isoform 6). /FTId=VSP_018016 VAR_SEQ 357 531 Missing (in isoform 5 and isoform 6) /FTId=VSP_018017 VAR_SEQ 489 489 Q -> QR (in isoform 2 and isoform 3) /FTId=VSP_018018 STRAND 59 65 {ECO:0000244|PDB:2CQ1} HELIX 72 77 {ECO:0000244|PDB:2CQ1} TURN 78 82 {ECO:0000244|PDB:2CQ1} STRAND 85 91 {ECO:0000244|PDB:2CQ1} TURN 92 95 {ECO:0000244|PDB:2CQ1} STRAND 96 103 {ECO:0000244|PDB:2CQ1} HELIX 104 116 {ECO:0000244|PDB:2CQ1} STRAND 127 130 {ECO:0000244|PDB:2CQ1} STRAND 339 344 {ECO:0000244|PDB:4CQ1} TURN 347 349 {ECO:0000244|PDB:4CQ1} HELIX 352 359 {ECO:0000244|PDB:4CQ1} TURN 360 362 {ECO:0000244|PDB:4CQ1} STRAND 365 371 {ECO:0000244|PDB:4CQ1} STRAND 374 384 {ECO:0000244|PDB:4CQ1} HELIX 385 395 {ECO:0000244|PDB:4CQ1} STRAND 400 403 {ECO:0000244|PDB:2MJU} STRAND 406 409 {ECO:0000244|PDB:4CQ1} STRAND 419 422 {ECO:0000244|PDB:2MJU} TURN 423 425 {ECO:0000244|PDB:2MJU} STRAND 428 430 {ECO:0000244|PDB:4CQ1} HELIX 431 433 {ECO:0000244|PDB:2MJU} HELIX 444 446 {ECO:0000244|PDB:4CQ1} STRAND 447 450 {ECO:0000244|PDB:2MJU} STRAND 455 460 {ECO:0000244|PDB:4CQ1} HELIX 468 476 {ECO:0000244|PDB:4CQ1} TURN 477 479 {ECO:0000244|PDB:4CQ1} STRAND 482 487 {ECO:0000244|PDB:4CQ1} STRAND 494 500 {ECO:0000244|PDB:4CQ1} HELIX 501 511 {ECO:0000244|PDB:4CQ1} STRAND 515 517 {ECO:0000244|PDB:4CQ1} STRAND 523 526 {ECO:0000244|PDB:4CQ1} SEQUENCE 531 AA; 57491 MW; 57ADA23F422AE02A CRC64; MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL LAVPGALSPL AIPNAAAAAA AAAAGRVGMP GVSAGGNTVL LVSNLNEEMV TPQSLFTLFG VYGDVQRVKI LYNKKDSALI QMADGNQSQL AMNHLNGQKM YGKIIRVTLS KHQTVQLPRE GLDDQGLTKD FGNSPLHRFK KPGSKNFQNI FPPSATLHLS NIPPSVAEED LRTLFANTGG TVKAFKFFQD HKMALLQMAT VEEAIQALID LHNYNLGENH HLRVSFSKST I
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References

A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, Ostrow K, Shiue L, Ares M Jr, Black DL. Genes Dev. 2007 Jul 1;21(13):1636-52. PMID: 17606642

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