|Other Accession||NP_067013.1, 58155, 56195 (mouse), 310820 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||57491 Da|
|Other Names||Polypyrimidine tract-binding protein 2, Neural polypyrimidine tract-binding protein, Neurally-enriched homolog of PTB, PTB-like protein, PTBP2, NPTB, PTB, PTBLP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTBP2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NPTB, PTB, PTBLP|
|Function||RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.|
|Tissue Location||Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues Isoform 3 and isoform 4 are expressed in non-neuronal tissues Isoform 5 and isoform 6 are truncated forms expressed in non- neuronal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, Ostrow K, Shiue L, Ares M Jr, Black DL. Genes Dev. 2007 Jul 1;21(13):1636-52. PMID: 17606642
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