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PTBP2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9UKA9 |
| Other Accession | NP_067013.1, 58155, 56195 (mouse), 310820 (rat) |
| Predicted | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 57491 Da |
| Gene ID | 58155 |
|---|---|
| Other Names | Polypyrimidine tract-binding protein 2, Neural polypyrimidine tract-binding protein, Neurally-enriched homolog of PTB, PTB-like protein, PTBP2, NPTB, PTB, PTBLP |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTBP2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTBP2 (HGNC:17662) |
|---|---|
| Synonyms | NPTB, PTB, PTBLP |
| Function | RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q91Z31}. |
| Tissue Location | Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, Ostrow K, Shiue L, Ares M Jr, Black DL. Genes Dev. 2007 Jul 1;21(13):1636-52. PMID: 17606642
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