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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > PRICKLE3 / LMO6 Antibody (internal region)
PRICKLE3 / LMO6 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | O43900 |
| Other Accession | NP_006141.2, 4007, 317380 (rat) |
| Predicted | Human, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 68609 Da |
| Gene ID | 4007 |
|---|---|
| Other Names | Prickle-like protein 3, LIM domain only protein 6, LMO-6, Triple LIM domain protein 6, PRICKLE3, LMO6 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRICKLE3 / LMO6 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRICKLE3 (HGNC:6645) |
|---|---|
| Synonyms | LMO6 |
| Function | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. Cell membrane {ECO:0000250|UniProtKB:A8WH69}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WH69}; Cytoplasmic side {ECO:0000250|UniProtKB:A8WH69}. Mitochondrion. Note=Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity). {ECO:0000250|UniProtKB:A8WH69} |
| Tissue Location | Widely expressed. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. Fisher SE, Ciccodicola A, Tanaka K, Curci A, Desicato S, D'urso M, Craig IW. Genomics. 1997 Oct 15;45(2):340-7. PMID: 9344658
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$ 216.00
Cat# AF2649a
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