|Application ||IHC, E|
|Other Accession||NP_542432.2, 11219|
|Calculated MW||30621 Da|
|Other Names||Three prime repair exonuclease 2, 22.214.171.124, 3'-5' exonuclease TREX2, TREX2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TREX2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.|
|Tissue Location||Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. de Silva U, Choudhury S, Bailey SL, Harvey S, Perrino FW, Hollis T. J Biol Chem. 2007 Apr;282(14):10537-43. Epub 2007 Feb 9. PMID: 17293595
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