|Other Accession||NP_001005415.1, NP_001005416.1, NP_057580.3, 51257|
|Calculated MW||26995 Da|
|Other Names||E3 ubiquitin-protein ligase MARCH2, 6.3.2.-, Membrane-associated RING finger protein 2, Membrane-associated RING-CH protein II, MARCH-II, RING finger protein 172, MARCH2, RNF172|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MARCH2 / MARCH-II Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein|
|Tissue Location||Broadly expressed.|
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Provided below are standard protocols that you may find useful for product applications.
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. Nakamura N, Fukuda H, Kato A, Hirose S. Mol Biol Cell. 2005 Apr;16(4):1696-710. Epub 2005 Feb 2. PMID: 15689499
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