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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Goat Antibodies   >   EPB41L2 / 4.1G (aa 347 to 357) Antibody (internal region)   

EPB41L2 / 4.1G (aa 347 to 357) Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • IHC - EPB41L2  / 4.1G (aa 347 to 357) Antibody (internal region) AF2657a
    AF2657a (2.1 µg/ml) staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession O43491
Other Accession NP_001422.1, 2037
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Additional Information
Other Names Band 4.1-like protein 2, Generally expressed protein 4.1, 4.1G, EPB41L2
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEPB41L2 / 4.1G (aa 347 to 357) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPB41L2
Function Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell membrane
Tissue Location Widely expressed. EMBL; AF027299; AAC16923.1; -; mRNA EMBL; AY047584; AAK95850.1; -; mRNA EMBL; AK295124; BAG58150.1; -; mRNA EMBL; CR749262; CAH18118.1; -; mRNA EMBL; AL109938; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL357496; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL355360; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL358943; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL590014; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471051; EAW48062.1; -; Genomic_DNA CCDS; CCDS47474.1; -. [O43491-2] CCDS; CCDS5141.1; -. [O43491-1] CCDS; CCDS56450.1; -. [O43491-4] CCDS; CCDS59037.1; -. [O43491-3] RefSeq; NP_001129026.1; NM_001135554.1. [O43491-2] RefSeq; NP_001129027.1; NM_001135555.3. [O43491-2] RefSeq; NP_001239589.1; NM_001252660.1. [O43491-3] RefSeq; NP_001422.1; NM_001431.3. [O43491-1] RefSeq; XP_011533832.1; XM_011535530.1 RefSeq; XP_011533836.1; XM_011535534.1 RefSeq; XP_016865844.1; XM_017010355.1 RefSeq; XP_016865848.1; XM_017010359.1 RefSeq; XP_016865849.1; XM_017010360.1 RefSeq; XP_016865850.1; XM_017010361.1 RefSeq; XP_016865851.1; XM_017010362.1 UniGene; Hs.486470; - UniGene; Hs.708219; - ProteinModelPortal; O43491; - SMR; O43491; - BioGrid; 108351; 54 DIP; DIP-17034N; - IntAct; O43491; 30 STRING; 9606.ENSP00000338481; - iPTMnet; O43491; - PhosphoSitePlus; O43491; - BioMuta; EPB41L2; - EPD; O43491; - MaxQB; O43491; - PaxDb; O43491; - PeptideAtlas; O43491; - PRIDE; O43491; - ProteomicsDB; 48974; - ProteomicsDB; 48975; -. [O43491-2] TopDownProteomics; O43491-3; -. [O43491-3] Ensembl; ENST00000337057; ENSP00000338481; ENSG00000079819. [O43491-1] Ensembl; ENST00000368128; ENSP00000357110; ENSG00000079819. [O43491-1] Ensembl; ENST00000392427; ENSP00000376222; ENSG00000079819. [O43491-2] Ensembl; ENST00000445890; ENSP00000402041; ENSG00000079819. [O43491-3] Ensembl; ENST00000525271; ENSP00000432803; ENSG00000079819. [O43491-2] Ensembl; ENST00000528282; ENSP00000434308; ENSG00000079819. [O43491-3] Ensembl; ENST00000530481; ENSP00000434576; ENSG00000079819. [O43491-4] GeneID; 2037; - KEGG; hsa:2037; - UCSC; uc003qcg.2; human. [O43491-1] CTD; 2037; - DisGeNET; 2037; - EuPathDB; HostDB:ENSG00000079819.16; - GeneCards; EPB41L2; - HGNC; HGNC:3379; EPB41L2 HPA; HPA005730; - HPA; HPA006642; - MIM; 603237; gene neXtProt; NX_O43491; - OpenTargets; ENSG00000079819; - PharmGKB; PA27812; - eggNOG; KOG3527; Eukaryota eggNOG; ENOG410Y7NQ; LUCA GeneTree; ENSGT00760000118823; - HOGENOM; HOG000228841; - HOVERGEN; HBG007777; - InParanoid; O43491; - KO; K06107; - OMA; ISEFQFA; - OrthoDB; EOG091G00IL; - PhylomeDB; O43491; - TreeFam; TF351626; - Reactome; R-HSA-6794361; Neurexins and neuroligins ChiTaRS; EPB41L2; human GeneWiki; EPB41L2; - GenomeRNAi; 2037; - PRO; PR:O43491; - Proteomes; UP000005640; Chromosome 6 Bgee; ENSG00000079819; - CleanEx; HS_EPB41L2; - ExpressionAtlas; O43491; baseline and differential Genevisible; O43491; HS GO; GO:0099738; C:cell cortex region; IDA:UniProtKB GO; GO:0030054; C:cell junction; IDA:HPA GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0005925; C:focal adhesion; HDA:UniProtKB GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0005886; C:plasma membrane; IDA:HPA GO; GO:0008091; C:spectrin; TAS:ProtInc GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW GO; GO:0042731; F:PH domain binding; IEA:Ensembl GO; GO:0030507; F:spectrin binding; IEA:Ensembl GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW GO; GO:0051301; P:cell division; IEA:UniProtKB-KW GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro GO; GO:1904778; P:positive regulation of protein localization to cell cortex; IMP:UniProtKB CDD; cd14473; FERM_B-lobe; 1 Gene3D; 1.20.80.10; -; 1 Gene3D; 2.30.29.30; -; 1 InterPro; IPR008379; Band_4.1_C InterPro; IPR019749; Band_41_domain InterPro; IPR030546; E41L2 InterPro; IPR000798; Ez/rad/moesin-like InterPro; IPR014847; FERM-adjacent InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf InterPro; IPR035963; FERM_2 InterPro; IPR019748; FERM_central InterPro; IPR019747; FERM_CS InterPro; IPR000299; FERM_domain InterPro; IPR018979; FERM_N InterPro; IPR018980; FERM_PH-like_C InterPro; IPR011993; PH-like_dom_sf InterPro; IPR007477; SAB_dom InterPro; IPR029071; Ubiquitin-like_domsf PANTHER; PTHR23280:SF17; PTHR23280:SF17; 1 Pfam; PF05902; 4_1_CTD; 1 Pfam; PF08736; FA; 1 Pfam; PF09380; FERM_C; 1 Pfam; PF00373; FERM_M; 1 Pfam; PF09379; FERM_N; 1 Pfam; PF04382; SAB; 1 PRINTS; PR00935; BAND41 PRINTS; PR00661; ERMFAMILY SMART; SM00295; B41; 1 SMART; SM01195; FA; 1 SMART; SM01196; FERM_C; 1 SUPFAM; SSF47031; SSF47031; 1 SUPFAM; SSF54236; SSF54236; 1 PROSITE; PS00660; FERM_1; 1 PROSITE; PS00661; FERM_2; 1 PROSITE; PS50057; FERM_3; 1 1: Evidence at protein level; Acetylation; Actin-binding; Alternative splicing; Cell cycle; Cell division; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Membrane; Mitosis; Phosphoprotein; Polymorphism; Reference proteome; Transport; Ubl conjugation INIT_MET 1 1 Removed. {ECO:0000244|PubMed:19413330, ECO:0000244|PubMed:22223895, ECO:0000269|Ref.7} CHAIN 2 1005 Band 4.1-like protein 2 /FTId=PRO_0000219397 DOMAIN 218 499 FERM. {ECO:0000255|PROSITE- ProRule:PRU00084} REGION 502 610 Hydrophilic REGION 611 676 Spectrin--actin-binding REGION 855 1005 C-terminal (CTD) MOD_RES 2 2 N-acetylthreonine {ECO:0000244|PubMed:19413330, ECO:0000244|PubMed:22223895, ECO:0000269|Ref.7} MOD_RES 7 7 Phosphoserine MOD_RES 39 39 Phosphoserine MOD_RES 58 58 Phosphoserine MOD_RES 87 87 Phosphoserine MOD_RES 89 89 Phosphothreonine MOD_RES 170 170 Phosphoserine MOD_RES 208 208 Phosphoserine {ECO:0000250|UniProtKB:O70318} MOD_RES 386 386 Phosphoserine MOD_RES 402 402 Phosphoserine {ECO:0000250|UniProtKB:O70318} MOD_RES 499 499 Phosphoserine MOD_RES 550 550 Phosphoserine MOD_RES 562 562 Phosphoserine MOD_RES 575 575 Phosphoserine {ECO:0000250|UniProtKB:O70318} MOD_RES 598 598 Phosphoserine MOD_RES 614 614 Phosphoserine MOD_RES 623 623 Phosphotyrosine {ECO:0000250|UniProtKB:O70318} MOD_RES 627 627 Phosphoserine {ECO:0000250|UniProtKB:O70318} MOD_RES 647 647 Phosphoserine MOD_RES 715 715 Phosphoserine MOD_RES 718 718 Phosphoserine MOD_RES 763 763 Phosphothreonine {ECO:0000250|UniProtKB:O70318} MOD_RES 828 828 Phosphoserine CROSSLNK 140 140 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) CROSSLNK 144 144 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) VAR_SEQ 612 943 Missing (in isoform 2) /FTId=VSP_042910 VAR_SEQ 612 869 Missing (in isoform 3) /FTId=VSP_045090 VAR_SEQ 612 681 Missing (in isoform 4). /FTId=VSP_047181 VAR_SEQ 787 869 Missing (in isoform 4). /FTId=VSP_047182 VARIANT 17 17 Q -> H (in dbSNP:rs2297852) /FTId=VAR_020145 SEQUENCE 1005 AA; 112588 MW; E86CB17488F6045F CRC64; MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP PAAESQSSLR RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK EPTQAVVEEQ VLDKEEPLPE EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV SKEEKPSVSK VEMQPTELVS KEREEKVKET QEDKLEGGAA KRETKEVQTN ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG QVLFDKVCEH LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP EEHGSIDLSE FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR LSMYGVDLHH AKDSEGVDIK LGVCANGLLI YKDRLRINRF AWPKILKISY KRSNFYIKVR PAELEQFEST IGFKLPNHRA AKRLWKVCVE HHTFYRLVSP EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE RTSSKRVSRS LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE LKRNFMESTP EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK DERVITEEMN GKEISPGSGP GEIRKVEPVT QKDSTSLSSE SSSSSSESEE EDVGEYRPHH RVTEGTIREE QEYEEEVEEE PRPAAKVVER EEAVPEASPV TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE EAEEEPQKVN GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA EEGED
Research Areas
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References

The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large. Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF. J Biol Chem. 2004 Aug 6;279(32):33816-28. Epub 2004 May 11. PMID: 15138281

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