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TMPRSS4 (aa245-57) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NRS4 |
| Other Accession | NP_063947.1, NP_001077416.1, 56649 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 48246 Da |
| Gene ID | 56649 |
|---|---|
| Other Names | Transmembrane protease serine 4, 3.4.21.-, Channel-activating protease 2, CAPH2, Membrane-type serine protease 2, MT-SP2, TMPRSS4, TMPRSS3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMPRSS4 (aa245-57) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMPRSS4 (HGNC:11878) |
|---|---|
| Function | Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein |
| Tissue Location | High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported isoforms (NP_063947.1 and NP_001077416.1).
References
Structural templates predict novel protein interactions and targets from pancreas tumour gene expression data. Dawelbait G, Winter C, Zhang Y, Pilarsky C, Grutzmann R, Heinrich JC, Schroeder M. Bioinformatics. 2007 Jul 1;23(13):i115-24. PMID: 17646287
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