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MARCH-IV Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9P2E8 |
| Other Accession | NP_065865.1, 57574 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 45528 Da |
| Gene ID | 57574 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase MARCH4, 6.3.2.-, Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, MARCH4, KIAA1399, RNF174 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MARCH-IV Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MARCHF4 (HGNC:29269) |
|---|---|
| Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in brain and placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Downregulation of major histocompatibility complex class I by human ubiquitin
ligases related to viral immune evasion proteins. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K. J Virol. 2004 Feb;78(3):1109-20. PMID: 14722266
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