|Other Accession||NP_065865.1, 57574|
|Calculated MW||45528 Da|
|Other Names||E3 ubiquitin-protein ligase MARCH4, 6.3.2.-, Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, MARCH4, KIAA1399, RNF174|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MARCH-IV Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in brain and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Downregulation of major histocompatibility complex class I by human ubiquitin
ligases related to viral immune evasion proteins. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K. J Virol. 2004 Feb;78(3):1109-20. PMID: 14722266
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