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MARCH-IV Antibody (internal region)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P2E8
Other Accession NP_065865.1, 57574
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 45528 Da
Additional Information
Gene ID 57574
Other Names E3 ubiquitin-protein ligase MARCH4, 6.3.2.-, Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, MARCH4, KIAA1399, RNF174
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMARCH-IV Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1399, RNF174
Function E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Expressed in brain and placenta.
Research Areas
Citations (0)

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Downregulation of major histocompatibility complex class I by human ubiquitin
ligases related to viral immune evasion proteins. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K. J Virol. 2004 Feb;78(3):1109-20. PMID: 14722266

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$ 325.00
Cat# AF2695a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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