|Other Accession||NP_000865.2, NP_997467.1, NP_997468.1, 3455|
|Calculated MW||57759 Da|
|Other Names||Interferon alpha/beta receptor 2, IFN-R-2, IFN-alpha binding protein, IFN-alpha/beta receptor 2, Interferon alpha binding protein, Type I interferon receptor 2, IFNAR2, IFNABR, IFNARB|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFNAR2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted|
|Tissue Location||Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells Expressed in lymphoblastoid and fibrosarcoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise all three reported isoforms (NP_000865.2 ; NP_997467.1; NP_997468.1 )
Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. Keller BC, Fredericksen BL, Samuel MA, Mock RE, Mason PW, Diamond MS, Gale M Jr. J Virol. 2006 Oct;80(19):9424-34. PMID: 16973548
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