|Other Accession||NP_009206.1, 11334, 80385 (mouse), 501052 (rat)|
|Predicted||Human, Mouse, Rat|
|Calculated MW||12074 Da|
|Other Names||Tumor suppressor candidate 2, Fusion 1 protein, Fus-1 protein, PDGFA-associated protein 2, TUSC2, C3orf11, FUS1, LGCC, PDAP2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TUSC2 / FUS1 Antibody (interal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C3orf11, FUS1, LGCC, PDAP2|
|Function||May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.|
|Tissue Location||Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta|
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Provided below are standard protocols that you may find useful for product applications.
Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer cells Deng WG, Kawashima H, Wu G, Jayachandran G, Xu K, Minna JD, Roth JA, Ji L. Cancer Res. 2007 Jan 15;67(2):709-17. PMID: 17234782
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