|Other Accession||NP_000735.1, 1137|
|Calculated MW||69957 Da|
|Other Names||Neuronal acetylcholine receptor subunit alpha-4, CHRNA4, NACRA4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRNA4 Antibody (internal region, near the N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor|
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How mutations in the nAChRs can cause ADNFLE epilepsy. Bertrand D, Picard F, Le Hellard S, Weiland S, Favre I, Phillips H, Bertrand S, Berkovic SF, Malafosse A, Mulley J. Epilepsia. 2002;43 Suppl 5:112-22. PMID: 12121305
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