|Other Accession||NP_005798.2, 10216|
|Calculated MW||151077 Da|
|Other Names||Proteoglycan 4, Lubricin, Megakaryocyte-stimulating factor, Superficial zone proteoglycan, Proteoglycan 4 C-terminal part, PRG4, MSF, SZP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Lubricin / PRG4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.|
|Tissue Location||Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The role of lubricin in the mechanical behavior of synovial fluid. Jay GD, Torres JR, Warman ML, Laderer MC, Breuer KS. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6194-9. Epub 2007 Apr 2. PMID: 17404241
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