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ATP7A Antibody (internal region)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q04656
Other Accession NP_000043.3, 538
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 163374 Da
Additional Information
Gene ID 538
Other Names Copper-transporting ATPase 1,, Copper pump 1, Menkes disease-associated protein, ATP7A, MC1, MNK
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsATP7A Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP7A
Synonyms MC1, MNK
Function May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Cycles constitutively between the trans- Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels Isoform 5: Endoplasmic reticulum.
Tissue Location Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines
Research Areas
Citations (0)

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Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Schlief ML, West T, Craig AM, Holtzman DM, Gitlin JD. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14919-24. Epub 2006 Sep 26. PMID: 17003121

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$ 325.00
Cat# AF2750a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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