|Other Accession||NP_000043.3, 538|
|Calculated MW||163374 Da|
|Other Names||Copper-transporting ATPase 1, 184.108.40.206, Copper pump 1, Menkes disease-associated protein, ATP7A, MC1, MNK|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP7A Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Cycles constitutively between the trans-Golgi network (TGN) and the plasma membrane (PubMed:9147644) Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels Isoform 5: Endoplasmic reticulum|
|Tissue Location||Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Schlief ML, West T, Craig AM, Holtzman DM, Gitlin JD. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14919-24. Epub 2006 Sep 26. PMID: 17003121
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