|Other Accession||NP_057288.1, 2658|
|Calculated MW||47320 Da|
|Other Names||Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9, GDF2, BMP9|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GDF2/BMP9 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.|
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Provided below are standard protocols that you may find useful for product applications.
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, Löwik CW, ten Dijke P. J Cell Sci. 2007 Mar 15;120(Pt 6):964-72. Epub 2007 Feb 20. PMID: 17311849
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