|Other Accession||NP_150296.3, 10595|
|Calculated MW||102480 Da|
|Other Names||Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, 22.214.171.124, Endoribonuclease, 3.1.26.-, ERN2 (HGNC:16942)|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERN2 / IRE1b Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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PERK mediates cell-cycle exit during the mammalian unfolded protein response. Brewer JW, Diehl JA. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12625-30. PMID: 11035797
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