ERN2 / IRE1b Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | Q76MJ5 |
Other Accession | NP_150296.3, 10595 |
Predicted | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 102480 Da |
Gene ID | 10595 |
---|---|
Other Names | Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, 2.7.11.1, Endoribonuclease, 3.1.26.-, ERN2 (HGNC:16942) |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ERN2 / IRE1b Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ERN2 (HGNC:16942) |
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Function | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
References
PERK mediates cell-cycle exit during the mammalian unfolded protein response. Brewer JW, Diehl JA. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12625-30. PMID: 11035797
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