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FKBP8 / FKBP38 Antibody (internal region)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14318
Other Accession NP_036313.3, 23770, 14232 (mouse), 290652 (rat)
Predicted Human, Mouse, Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 44562 Da
Additional Information
Gene ID 23770
Other Names Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8,, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase, FKBP8, FKBP38
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFKBP8 / FKBP38 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FKBP8
Synonyms FKBP38
Function Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Cellular Location Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side
Tissue Location Widely expressed. Highest levels seen in the brain. Highly abundant in the retina
Research Areas
Citations (0)

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Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M. Hum Mol Genet. 2005 Jul 1;14(13):1889-902. Epub 2005 May 19. PMID: 15905180

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$ 325.00
Cat# AF2768a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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