|Other Accession||NP_036313.3, 23770, 14232 (mouse), 290652 (rat)|
|Predicted||Human, Mouse, Rat, Dog, Cow|
|Calculated MW||44562 Da|
|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8, 22.214.171.124, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase, FKBP8, FKBP38|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FKBP8 / FKBP38 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.|
|Cellular Location||Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side Isoform 3: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side|
|Tissue Location||Widely expressed. Highest levels seen in the brain. Highly abundant in the retina|
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Provided below are standard protocols that you may find useful for product applications.
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M. Hum Mol Genet. 2005 Jul 1;14(13):1889-902. Epub 2005 May 19. PMID: 15905180
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