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RNF212 Antibody (internal region)

Peptide-affinity purified goat antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q495C1
Other Accession NP_919420.1, 285498
Predicted Human, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 33365 Da
Additional Information
Gene ID 285498
Other Names Probable E3 SUMO-protein ligase RNF212, 6.3.2.-, RING finger protein 212, RNF212
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRNF212 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF212
Function SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).
Cellular Location Nucleus. Chromosome. Note=Associates to the synaptonemal complex Localizes to a minority of double-strand breaks (DSBs) sites Marks crossover sites during midpachynema (By similarity)
Research Areas
Citations (0)

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Sequence Variants in the RNF212 Gene Associate with Genomewide Recombination Rate Kong A, Thorleifsson G, Stefansson H, Masson G, Helgason A, Gudbjartsson DF, Jonsdottir GM, Gudjonsson SA, Sverrisson S, Thorlacius T, Jonasdottir A, Hardarson GA, Palsson ST, Frigge ML, Gulcher JR, Thorsteinsdottir U, Stefansson K Science. 2008 Jan 31 PMID: 18239089

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$ 325.00
Cat# AF2771a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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