|Other Accession||NP_919420.1, 285498|
|Calculated MW||33365 Da|
|Other Names||Probable E3 SUMO-protein ligase RNF212, 6.3.2.-, RING finger protein 212, RNF212|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNF212 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Associates to the synaptonemal complex Localizes to a minority of double-strand breaks (DSBs) sites Marks crossover sites during midpachynema (By similarity)|
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Provided below are standard protocols that you may find useful for product applications.
Sequence Variants in the RNF212 Gene Associate with Genomewide Recombination Rate Kong A, Thorleifsson G, Stefansson H, Masson G, Helgason A, Gudbjartsson DF, Jonsdottir GM, Gudjonsson SA, Sverrisson S, Thorlacius T, Jonasdottir A, Hardarson GA, Palsson ST, Frigge ML, Gulcher JR, Thorsteinsdottir U, Stefansson K Science. 2008 Jan 31 PMID: 18239089
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